Compound Q&A

How is Trifluoroacetonitrile (CAS: 353-85-5) typically synthesized?

Answer

Trifluoroacetonitrile
Trifluoroacetonitrile (CAS: 353-85-5) is typically synthesized by the radical addition of trifluoroacetic acid to acetonitrile. This reaction can be catalyzed by UV light or other initiators. The process is highly selective and generally yields a purifiable product. Other methods include the fluoride-mediated reaction of acetonitrile with trifluoroacetic anhydride, although this route is less common.

About

CAS No 353-85-5
English Name Trifluoroacetonitrile
Molecular Formula C2F3N
Molecular Weight 84.04 g/mol
SMILES C(#N)C(F)(F)F
InChIKey SFFUEHODRAXXIA-UHFFFAOYSA-N
Last Updated: 2025-10-26 09:39

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