Compound Q&A
How is (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-diene-16,21-diyl diacetate (CAS: 67-78-7) typically synthesized?
Answer
This compound is typically synthesized through a multi-step process involving the conversion of a pregnane derivative to the fluoro-diol intermediate, followed by acetylation. Commonly used catalysts include sulfuric acid or trifluoromethanesulfonic acid. The overall yield is approximately 60-70%, with good selectivity towards the desired diacetate product.
About
CAS No
67-78-7
English Name
(11beta,16alpha)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-diene-16,21-diyl diacetate
Molecular Formula
C25H31FO8
Molecular Weight
478.5 g/mol
SMILES
CC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)OC(=O)C)O
InChIKey
XGMPVBXKDAHORN-RBWIMXSLSA-N
Last Updated: 2025-10-26 09:38
