Compound Q&A
How is 1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea (CAS: 228559-41-9) typically synthesized?
Answer
![1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea](https://static.chemtradehub.com/structs/228/228559-41-9-5520.webp "1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea")
1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea is synthesized via a multi-step process, involving the coupling of 2,4-difluorophenyl isocyanate with 4-(2-fluoro-phenyl)-6,7-dimethoxy-4H-quinol-3-one. The synthesis typically requires the use of a base like triethylamine and a suitable solvent such as dimethylformamide (DMF). The yield is around 70%, and the product is purified by recrystallization from ethanol.
About
CAS No
228559-41-9
English Name
1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea
Molecular Formula
C24H18F3N3O4
Molecular Weight
469.42 g/mol
SMILES
O=C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1F)NC4=CC=C(F)C=C4F
InChIKey
LFKQSJNCVRGFCC-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31
![1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea — Shanghai Jixiang Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}
![1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}