1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea(CAS: 228559-41-9)

1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea is a white crystalline solid with a molecular weight of approximately 609.3 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and acetonitrile. This compound is moderately reactive towards nucleophiles and basic conditions. It exhibits good stability under neutral and slightly acidic conditions.

1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea is synthesized via a multi-step process, involving the coupling of 2,4-difluorophenyl isocyanate with 4-(2-fluoro-phenyl)-6,7-dimethoxy-4H-quinol-3-one. The synthesis typically requires the use of a base like triethylamine and a suitable solvent such as dimethylformamide (DMF). The yield is around 70%, and the product is purified by recrystallization from ethanol.

1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea is used in the pharmaceutical industry for its potential biological activities. It shows promise in antiviral and antitumor applications. This compound may also have relevance in the polymer industry, particularly in the development of functional polymers and in the production of advanced materials for electronic devices and sensors.

When handling 1-(2,4-Difluorophenyl)-3-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl}urea (CAS: 228559-41-9), appropriate personal protective equipment (PPE) should be worn, including gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be handled using appropriate absorbents, and the area should be cleaned with a suitable solvent. Always consult the Safety Data Sheet (SDS) for detailed information on handling and disposal procedures.