How is (2R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid (CAS: 20445-31-2) typically synthesized?

(2R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid is synthesized through a multi-step process involving the protection of the phenolic hydroxyl group, fluoroalkylation, and deprotection. Commonly, the synthesis involves using fluoroform, phenol, and appropriate protecting agents such as tert-butyldimethylsilyl chloride. The reaction typically yields a mixture of stereoisomers, and enantioselective methods can be employed for higher selectivity.