How is Edoxaban Impurity 67 (CAS: 143150-92-9) typically synthesized?

Edoxaban Impurity 67 (CAS: 143150-92-9) is synthesized through a series of chemical reactions involving the parent compound, edoxaban. The process typically includes steps such as hydrolysis and cyclization, using appropriate catalysts to enhance selectivity and yield. The reaction conditions are carefully controlled to minimize the formation of other impurities, ensuring the purity of the end product.