How is 5-Bromo-2-chloro-3-iodopyridine (CAS: 928653-73-0) typically synthesized?

5-Bromo-2-chloro-3-iodopyridine is typically synthesized via the substitution of chlorine and bromine in pyridine followed by iodination. Common synthetic routes involve the use of bromine and iodine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is selective and yields a high percentage of the desired product, but proper handling of halogens and iodine is required to prevent side reactions and ensure safety.