Compound Q&A
How is N-(2,6-Dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-2-oxoethyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide (CAS: 841301-32-4) typically synthesized?
Answer
![N-(2,6-Dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-2-oxoethyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide](https://static.chemtradehub.com/structs/841/841301-32-4-d5e9.webp "N-(2,6-Dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-2-oxoethyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide")
This compound is typically synthesized via a multi-step process involving the reaction of a 2-oxoethylamine derivative with a 2,6-dimethylphenylthiopyran-4-carboxylic acid derivative. The synthesis employs a catalytic amount of a suitable Lewis acid, such as ZnCl2, and proceeds in organic solvents like dichloromethane. The yield is generally around 70-80%, and the reaction is known for its good selectivity.
About
CAS No
841301-32-4
English Name
N-(2,6-Dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-2-oxoethyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide
Molecular Formula
C24H26N4O5S
Molecular Weight
482.56 g/mol
SMILES
Cc1cccc(c1N(CC(=O)Nc2ccc(cc2)c3ncon3)C(=O)C4CCS(=O)(=O)CC4)C
InChIKey
MNHNIVNAFBSLLX-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37
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