How is Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6) typically synthesized?

Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6) is synthesized through the iodination of methyl 3-hydroxybenzoate under the use of iodine and a suitable base such as potassium carbonate. The reaction is typically conducted in a polar aprotic solvent like dimethylformamide (DMF) at room temperature. The product is isolated by recrystallization from a mixture of ethanol and water, yielding a high purity crystalline solid with a yield of around 85-90%.