Methyl 3-hydroxy-4-iodobenzoate(CAS: 157942-12-6)

Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6) is a white crystalline solid with a molecular weight of approximately 287.03 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like methanol and ethanol. This compound is reactive towards nucleophiles and electrophiles, making it suitable for various synthetic transformations. It crystallizes in the monoclinic system and is stable under normal laboratory conditions.

Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6) is synthesized through the iodination of methyl 3-hydroxybenzoate under the use of iodine and a suitable base such as potassium carbonate. The reaction is typically conducted in a polar aprotic solvent like dimethylformamide (DMF) at room temperature. The product is isolated by recrystallization from a mixture of ethanol and water, yielding a high purity crystalline solid with a yield of around 85-90%.

Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6) is primarily used in the pharmaceutical industry for the synthesis of intermediates in drug development. It also has applications in the polymer industry as a monomer for the production of functionalized polymers. Additionally, it is used in the chemical sensor industry due to its unique reactivity towards certain analytes.

When handling Methyl 3-hydroxy-4-iodobenzoate (CAS: 157942-12-6), it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound must be handled in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately with the use of appropriate absorbent materials. In case of skin contact, wash with copious amounts of water. For more detailed safety information, refer to the safety data sheet (SDS) for this compound.