Compound Q&A

How is 2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 140695-84-7) typically synthesized?

Answer

2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate
2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate is typically synthesized via the reaction of 2-methylpropionyl chloride with (S)-2-(hydroxymethyl)-1-piperidine ethanol in the presence of a base such as sodium hydride. The yield is generally around 70-80%, and the reaction is carried out in an anhydrous solvent like tetrahydrofuran (THF).

About

English Name 2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate
Molecular Formula C11H21NO3
Molecular Weight 215.29 g/mol
SMILES CC(C)(C)OC(=O)N1CCCC(C1)CO
InChIKey OJCLHERKFHHUTB-VIFPVBQESA-N
Last Updated: 2025-10-19 20:30

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