2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate(CAS: 140695-84-7)

2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate is a crystalline compound with a molecular weight of approximately 236.34 g/mol. It is slightly soluble in water and ethanol. This compound exhibits good reactivity towards nucleophiles and can undergo esterification and hydrolysis reactions. Its theoretical melting point is around 115-118°C.

2-Methyl-2-propanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate is typically synthesized via the reaction of 2-methylpropionyl chloride with (S)-2-(hydroxymethyl)-1-piperidine ethanol in the presence of a base such as sodium hydride. The yield is generally around 70-80%, and the reaction is carried out in an anhydrous solvent like tetrahydrofuran (THF).

2-Methyl-2-proanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate is used primarily in the pharmaceutical industry for the synthesis of various medicinals. It is also employed in the polymer industry for the development of advanced materials. Additionally, it has applications in the sensor technology and semiconductor industries due to its unique chemical properties.

When handling 2-Methyl-2-proanyl (3S)-3-(hydroxymethyl)-1-piperidinecarboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be used in a well-ventilated area or under a fume hood to avoid inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the Safety Data Sheet (SDS) for detailed guidance on handling and disposal.