Compound Q&A
How is 5-Chloro-6-methoxynicotinic acid (CAS: 884494-85-3) typically synthesized?
Answer
5-Chloro-6-methoxynicotinic acid is typically synthesized through the methylation of nicotinic acid followed by chlorination. Commonly, nicotinic acid is treated with methyl iodide in the presence of a base like sodium hydroxide to form the methoxy derivative, which is then chlorinated using thionyl chloride. The overall yield is around 75-85%.
About
CAS No
884494-85-3
English Name
5-Chloro-6-methoxynicotinic acid
Molecular Formula
C7H6ClNO3
Molecular Weight
187.58 g/mol
SMILES
COC1=C(C=C(C=N1)C(=O)O)Cl
InChIKey
FUBFUAARMGZWPE-UHFFFAOYSA-N
Last Updated: 2025-10-19 20:30
