Compound Q&A
How is (1R)-7-Hydroxy-1-(4-hydroxybenzyl)-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium (CAS: 6801-40-7) typically synthesized?
Answer
The synthesis of (1R)-7-Hydroxy-1-(4-hydroxybenzyl)-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium involves the condensation of 4-hydroxybenzaldehyde with 7-hydroxy-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoline followed by amination under basic conditions. The reaction is typically carried out in the presence of a catalyst such as sodium hydroxide. The overall yield is around 75-85%, and the product is isolated by recrystallization from ethanol.
About
CAS No
6801-40-7
English Name
(1R)-7-Hydroxy-1-(4-hydroxybenzyl)-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium
Molecular Formula
C19H24NO3
Molecular Weight
314.4 g/mol
SMILES
C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)O)OC)C
InChIKey
CLWOXNLVWMXBRD-QGZVFWFLSA-O
Last Updated: 2025-10-19 20:30
