Compound Q&A
How is Nesiritide (CAS: 124584-08-3) typically synthesized?
Answer
Nesiritide (CAS: 124584-08-3) is synthesized through solid-phase peptide synthesis. The process involves sequential coupling of protected amino acids to a solid support. Commonly used protecting groups include Boc (tert-butyloxycarbonyl) and Fmoc (9-fluorenylmethoxycarbonyl). The final product is cleaved from the solid support and purified using techniques such as HPLC. The overall yield is typically around 50-70%, depending on the purity and quality of intermediates.
About
CAS No
124584-08-3
English Name
Nesiritide
Molecular Formula
C143H244N50O42S4
Molecular Weight
3464 g/mol
SMILES
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CCSC)CCCCN)CCCNC(=N)N)CC2=CC=CC=C2)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C3CCCN3C(=O)C(CO)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CNC=N4)C(=O)O)CC(C)C)CO)CO)CO)CO
InChIKey
HPNRHPKXQZSDFX-OAQDCNSJSA-N
Last Updated: 2025-10-19 13:36
