Nesiritide(CAS: 124584-08-3)

Nesiritide (CAS: 124584-08-3) is a synthetic form of brain natriuretic peptide (BNP). It is a crystalline compound with a molecular weight of approximately 13,487 Da. Nesiritide is highly soluble in water and slightly soluble in ethanol. It is relatively stable under normal storage conditions but may degrade when exposed to heat, light, and air. Proper storage in a cool, dry place is recommended to preserve its efficacy.

Nesiritide (CAS: 124584-08-3) is synthesized through solid-phase peptide synthesis. The process involves sequential coupling of protected amino acids to a solid support. Commonly used protecting groups include Boc (tert-butyloxycarbonyl) and Fmoc (9-fluorenylmethoxycarbonyl). The final product is cleaved from the solid support and purified using techniques such as HPLC. The overall yield is typically around 50-70%, depending on the purity and quality of intermediates.

Nesiritide (CAS: 124584-08-3) is primarily used in the pharmaceutical industry for the treatment of acute decompensated heart failure. It is also of interest in research for its potential applications in the diagnosis and management of various cardiac conditions. Additionally, it has applications in biosensors and medical devices, although its use in these areas is more limited compared to its pharmaceutical applications.

When handling Nesiritide (CAS: 124584-08-3), it is important to wear appropriate personal protective equipment (PPE) such as gloves and lab coat. Ensure the work area is well-ventilated, ideally using a fume hood, to minimize exposure to the substance. Spills should be cleaned up immediately using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed safety information and emergency procedures.