Compound Q&A
How is 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol (CAS: 368-63-8) typically synthesized?
Answer
1-(3,5-Bis(trifluoromethyl)phenyl)ethanol can be synthesized via a trifluoromethylation reaction of an ethyl phenyl ether with triflic anhydride. The process involves the use of anhydrous conditions and a catalytic amount of a Lewis acid. The reaction is highly selective and provides good yields, typically around 80-90%. This method ensures the formation of the desired product with high purity.
About
CAS No
368-63-8
English Name
1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Molecular Formula
C10H8F6O
Molecular Weight
258.16 g/mol
SMILES
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O
InChIKey
MMSCIQKQJVBPIR-UHFFFAOYSA-N
Last Updated: 2025-10-19 13:36
