What regulatory guidelines apply to 1,3-Dioxan-2-one (CAS: 2453-03-4)?

1,3-Dioxan-2-one (CAS: 2453-03-4) must comply with various regulatory guidelines. Globally Harmonized System (GHS) categorizes it as a Category 2 skin irritant. In the European Union, it is subject to the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation, which requires manufacturers and importers to register and assess the substance's impact on human health and the environment. The Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) may have specific requirements for its use in pharmaceutical or chemical products, respectively, including proper labeling and handling procedures.