How is 1-Ethynyl-3,5-dimethoxybenzene (CAS: 171290-52-1) typically synthesized?

1-Ethynyl-3,5-dimethoxybenzene can be synthesized by the alkylation of 1,3,5-trimethoxybenzene with acetylene using a catalyst such as cuprates or zinc chloride. The reaction is typically carried out in anhydrous conditions to avoid side reactions. The product can be isolated by recrystallization and has a yield of around 85%. Other methods include the direct reaction of methoxybenzene with acetylene or the use of other transition metal catalysts.