1-Ethynyl-3,5-dimethoxybenzene(CAS: 171290-52-1)

1-Ethynyl-3,5-dimethoxybenzene is a crystalline solid with a molecular weight of approximately 224.25 g/mol. It has a low solubility in water (approximately 0.025 g/100 mL at 25°C) but is soluble in organic solvents like methanol and ethanol. The compound is relatively stable under normal conditions but can react with strong oxidizing agents. It can be synthesized by various methods and is used in the synthesis of other chemical compounds.

1-Ethynyl-3,5-dimethoxybenzene can be synthesized by the alkylation of 1,3,5-trimethoxybenzene with acetylene using a catalyst such as cuprates or zinc chloride. The reaction is typically carried out in anhydrous conditions to avoid side reactions. The product can be isolated by recrystallization and has a yield of around 85%. Other methods include the direct reaction of methoxybenzene with acetylene or the use of other transition metal catalysts.

1-Ethynyl-3,5-dimethoxybenzene is used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also used in the polymer industry for the production of certain types of plastics and in the semiconductor industry for the fabrication of electronic components. Additionally, it has applications in the production of sensors and other specialized chemical products.

Proper handling of 1-Ethynyl-3,5-dimethoxybenzene requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate disposal methods. Care should be taken to avoid contact with skin and eyes. Always consult the Safety Data Sheet (SDS) for detailed handling and storage information.