Compound Q&A
How is 4-[(Trifluoromethyl)sulfanyl]benzoic acid (CAS: 330-17-6) typically synthesized?
Answer
![4-[(Trifluoromethyl)sulfanyl]benzoic acid](https://static.chemtradehub.com/structs/330/330-17-6-a8a8.webp "4-[(Trifluoromethyl)sulfanyl]benzoic acid")
4-[(Trifluoromethyl)sulfanyl]benzoic acid is typically synthesized via the sulfonation of 4-bromobenzoic acid using trifluoromethanesulfonic anhydride. The reaction is carried out in the presence of a phase transfer catalyst such as tetrabutylammonium bromide to enhance the yield and selectivity. The process usually involves multiple steps and requires careful control of reaction conditions to achieve the desired product.
About
CAS No
330-17-6
English Name
4-[(Trifluoromethyl)sulfanyl]benzoic acid
Molecular Formula
C8H5F3O2S
Molecular Weight
222.19 g/mol
SMILES
C1=CC(=CC=C1C(=O)O)SC(F)(F)F
InChIKey
UMOGQQWVQUQTQA-UHFFFAOYSA-N
Last Updated: 2025-10-13 17:50
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