Compound Q&A
How is Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6) typically synthesized?
Answer
Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6) is typically synthesized via the reaction of 2-chloro-1,3-thiazole-5-carboxylic acid with ethylamine. This process involves heating the mixture under basic conditions, with the use of sodium hydroxide as a catalyst. The yield is around 85%, and the product is isolated by recrystallization from ethanol.
About
CAS No
81449-93-6
English Name
Ethyl 2-chloro-1,3-thiazole-5-carboxylate
Molecular Formula
C6H6ClNO2S
Molecular Weight
191.64 g/mol
SMILES
CCOC(=O)C1=CN=C(S1)Cl
InChIKey
IZIJOEOJKFKHQR-UHFFFAOYSA-N
Last Updated: 2025-10-13 15:08
