Ethyl 2-chloro-1,3-thiazole-5-carboxylate(CAS: 81449-93-6)

Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6) is a white crystalline solid with a molecular weight of approximately 229.67 g/mol. It has a solubility of about 4.5 g/L in water and is slightly soluble in ethanol. It is moderately reactive, particularly in acidic conditions. The compound is stable under normal storage conditions but should be protected from moisture and strong bases.

Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6) is typically synthesized via the reaction of 2-chloro-1,3-thiazole-5-carboxylic acid with ethylamine. This process involves heating the mixture under basic conditions, with the use of sodium hydroxide as a catalyst. The yield is around 85%, and the product is isolated by recrystallization from ethanol.

Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6) is used in various industries, particularly in the pharmaceutical sector for its potential as an intermediate in the synthesis of antifungal and antibacterial drugs. It is also utilized in the production of some agrochemicals and as a reagent in organic synthesis.

When handling Ethyl 2-chloro-1,3-thiazole-5-carboxylate (CAS: 81449-93-6), it is important to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up carefully and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.