How is Dimethyl 5-bromoisophthalate (CAS: 51760-21-5) typically synthesized?

Dimethyl 5-bromoisophthalate (CAS: 51760-21-5) can be synthesized through the bromination of isophthalic acid followed by esterification with dimethyl alcohol. A common method involves the use of bromine in the presence of a base like sodium hydroxide. The reaction is typically carried out in an organic solvent such as methanol, and the yield can reach up to 85% with good selectivity. This compound is often used as an intermediate in the synthesis of other organic compounds.