Compound Q&A
How is 6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide (CAS: 1194506-26-7) typically synthesized?
Answer
![6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide](https://static.chemtradehub.com/structs/119/1194506-26-7-7b01.webp "6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide")
The compound can be synthesized through a multi-step process involving the condensation of dimethyl 1-benzofuran-3-carboxylate with 6,7-dimethoxy-4-quinazolinone. This reaction is typically catalyzed by a Lewis acid such as aluminum chloride. The overall yield is moderate, around 50-60%, with good selectivity towards the desired product.
About
CAS No
1194506-26-7
English Name
6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide
Molecular Formula
C21H19N3O5
Molecular Weight
393.4 g/mol
SMILES
CNC(=O)c1c(C)oc2c1ccc(c2)Oc1ncnc2c1cc(OC)c(c2)OC
InChIKey
BALLNEJQLSTPIO-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
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