Compound Q&A
How is 2-Amino-3,3,3-trifluoropropanoic acid hydrochloride (CAS: 96105-72-5) typically synthesized?
Answer
2-Amino-3,3,3-trifluoropropanoic acid hydrochloride is often synthesized by the reaction of 3,3,3-trifluoropropylamine with carbon dioxide under basic conditions to form the carboxamide, followed by acidification to form the hydrochloride salt. Common solvents include dimethyl sulfoxide (DMSO) and water. The reaction typically has good yield and selectivity, with the trifluoro substituents leading to stable intermediates.
About
CAS No
96105-72-5
English Name
2-Amino-3,3,3-trifluoropropanoic acid hydrochloride
Molecular Formula
C3H5ClF3NO2
Molecular Weight
179.52 g/mol
SMILES
C(C(=O)O)(C(F)(F)F)N.Cl
InChIKey
MRYBJJRPTNOPQK-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
