How is (2R)-3-Butyn-2-ol (CAS: 42969-65-3) typically synthesized?

(2R)-3-Butyn-2-ol can be synthesized via hydrogenation of 3-butyne followed by hydroxylation. Alternatively, it can be prepared by the reduction of 2-bromobutane with sodium borohydride. The synthesis often involves the use of transition metal catalysts and requires careful control of reaction conditions to achieve high selectivity and yield.