Compound Q&A
How is 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine (CAS: 71149-52-5) typically synthesized?
Answer
![4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine](https://static.chemtradehub.com/structs/711/71149-52-5-9467.webp "4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine")
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine can be synthesized through the condensation of 2-chloro-4-methylpyrimidine with 1,3-dihydro-2H-pyrrole. The reaction is typically carried out in the presence of a base such as potassium carbonate. The yield is around 70-80% and the reaction is selective with high stereoselectivity. The product can be purified by recrystallization from organic solvents.
About
CAS No
71149-52-5
English Name
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
Molecular Formula
C7H6ClN3
Molecular Weight
167.6 g/mol
SMILES
CC1=NC2=C(C=CN2)C(=N1)Cl
InChIKey
HCFJHJBEGJJOMO-UHFFFAOYSA-N
Last Updated: 2025-10-10 21:10
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