4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine(CAS: 71149-52-5)

4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine is a crystalline solid with a molecular weight of approximately 220.57 g/mol. It has a low water solubility and is moderately soluble in organic solvents like DMSO and acetonitrile. This compound is known for its low reactivity under normal conditions but can undergo substitution reactions under appropriate conditions. It is stable under standard storage conditions but should be protected from moisture and heat.

4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine can be synthesized through the condensation of 2-chloro-4-methylpyrimidine with 1,3-dihydro-2H-pyrrole. The reaction is typically carried out in the presence of a base such as potassium carbonate. The yield is around 70-80% and the reaction is selective with high stereoselectivity. The product can be purified by recrystallization from organic solvents.

4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine is primarily used in the pharmaceutical industry for intermediates in the synthesis of drugs. It is also used in the chemical industry for the production of polymers and as a precursor for the development of new materials. Additionally, it has applications in the synthesis of sensors and semiconductors.

When handling 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine (CAS: 71149-52-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from moisture and heat. It should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be cleaned up using appropriate methods and materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.