Compound Q&A
How is (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone (CAS: 163222-32-0) typically synthesized?
Answer
![(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone](https://static.chemtradehub.com/structs/163/163222-32-0-a2c2.webp "(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone")
(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone is typically synthesized via multistep organic synthesis involving benzyl protection, fluorene introduction, and azetidinone formation. Commonly used catalysts include palladium-based catalysts for cross-coupling reactions. The overall yield is typically around 60-70%, with high selectivity for the desired stereochemistry.
About
CAS No
163222-32-0
English Name
(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone
Molecular Formula
C31H27F2NO3
Molecular Weight
499.56 g/mol
SMILES
C1=CC=C(C=C1)COC2=CC=C(C=C2)C3C(C(=O)N3C4=CC=C(C=C4)F)CCC(C5=CC=C(C=C5)F)O
InChIKey
KEYVFYMGVLFXQK-DYIKCSJPSA-N
Last Updated: 2025-10-10 21:10
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