(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone(CAS: 163222-32-0)

(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone is a white to off-white crystalline solid with a molecular weight of approximately 563.5 g/mol. It has limited water solubility and is more soluble in organic solvents like methanol and DMSO. This compound shows moderate reactivity towards nucleophiles and can undergo ring-opening reactions under certain conditions. It is stable under normal storage conditions but should be stored in a cool, dark place to prevent degradation.

(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone is typically synthesized via multistep organic synthesis involving benzyl protection, fluorene introduction, and azetidinone formation. Commonly used catalysts include palladium-based catalysts for cross-coupling reactions. The overall yield is typically around 60-70%, with high selectivity for the desired stereochemistry.

(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone is used in the pharmaceutical industry for the development of novel drug candidates due to its specific chemical structure. It may also have applications in the polymer industry, where it can serve as a precursor for certain polymerization reactions. Additionally, it could find use in sensor technology and semiconductor manufacturing, though its use in these areas is less common.

When handling (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handling should be done in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local waste management regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.