Compound Q&A
How is Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (CAS: 1454-53-1) typically synthesized?
Answer
Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride is typically synthesized via a multistep process involving the condensation of ethyl 3-piperidinecarboxylate with benzylamine followed by hydrolysis and subsequent neutralization with hydrochloric acid. Commonly used catalysts include sodium hydride or potassium carbonate. The reaction yields are generally around 85-90%, and the product is isolated by recrystallization from an appropriate solvent.
About
CAS No
1454-53-1
English Name
Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (1:1)
Molecular Formula
C15H20ClNO3
Molecular Weight
297.78 g/mol
SMILES
CCOC(=O)C1CN(CCC1=O)CC2=CC=CC=C2.Cl
InChIKey
YPFMNHZRNXPYBG-UHFFFAOYSA-N
Last Updated: 2025-10-10 13:51
