How is (9S)-9-Amino-9-deoxoerythromycin (CAS: 26116-56-3) typically synthesized?

(9S)-9-Amino-9-deoxoerythromycin is synthesized through a multi-step process starting from erythromycin or deoxoerythromycin. The key steps include chemical modifications such as demethylation, reduction, and amino substitution. The synthesis typically requires the use of catalysts like palladium on carbon and specific reagents, with good selectivity and yield. The final step involves the introduction of the amino group at position 9, followed by derivatization to obtain the desired product.