Compound Q&A
How is 2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide (CAS: 722544-51-6) typically synthesized?
Answer
![2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide](https://static.chemtradehub.com/structs/722/722544-51-6-413d.webp "2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide")
The compound is synthesized via a multi-step process involving the reaction of a quinazoline derivative with an amine and pyrazole. The synthesis typically uses catalytic amounts of a base like potassium carbonate and is carried out under mild conditions. The yield is around 75%, and the product is isolated by recrystallization from ethanol.
About
CAS No
722544-51-6
English Name
2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
Molecular Formula
C26H30FN7O3
Molecular Weight
507.57 g/mol
SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
InChIKey
QYZOGCMHVIGURT-UHFFFAOYSA-N
Last Updated: 2025-10-07 19:42
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