Compound Q&A
How is 1,2-Dichloro-4-methyl-5-(trifluoromethyl)benzene (CAS: 74483-51-5) typically synthesized?
Answer
1,2-Dichloro-4-methyl-5-(trifluoromethyl)benzene is synthesized via Friedel-Crafts alkylation and electrophilic aromatic substitution reactions. Commonly, it is prepared from benzene, methyl triflate, and chlorine in the presence of aluminum chloride as a catalyst. The reaction is conducted under anhydrous conditions and requires careful control of temperature and reagent ratios to achieve high selectivity and yield.
About
CAS No
74483-51-5
English Name
1,2-Dichloro-4-methyl-5-(trifluoromethyl)benzene
Molecular Formula
C8H5Cl2F3
Molecular Weight
229.03 g/mol
SMILES
CC1=CC(=C(C=C1C(F)(F)F)Cl)Cl
InChIKey
OARYHYOOIUIKFZ-UHFFFAOYSA-N
Last Updated: 2025-10-05 08:54
