Compound Q&A
How is 5-Ethynyl-2'-deoxyuridine (EdU) (CAS: 61135-33-9) typically synthesized?
Answer
5-Ethynyl-2'-deoxyuridine (EdU) is typically synthesized via a multi-step process involving the reaction of 2'-deoxyuridine with acetylene and a catalyst such as sodium hydride. The reaction is carried out in a polar solvent like dimethylformamide (DMF) under anhydrous conditions to achieve high yield and selectivity. The process is carefully monitored to ensure optimal conditions for the formation of the ethynyl group.
About
CAS No
61135-33-9
English Name
5-Ethynyl-2'-deoxyuridine (EdU)
Molecular Formula
C11H12N2O5
Molecular Weight
252.22 g/mol
SMILES
OC[C@@H]1[C@H](C[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1)O
InChIKey
CDEURGJCGCHYFH-DJLDLDEBSA-N
Last Updated: 2025-10-01 13:51
