Compound Q&A
How is Amprenavir (CAS: 161814-49-9) typically synthesized?
Answer
Amprenavir is synthesized through a multi-step process involving the condensation of a 3,4-dihydroxybenzylamine derivative with a 2,4-dichlorobenzoyl chloride. The key steps include protection of the hydroxyl groups, coupling, and deprotection. Common catalysts include triethylamine and HATU. The overall yield is around 70-75%.
About
CAS No
161814-49-9
English Name
Amprenavir
Molecular Formula
C25H35N3O6S
Molecular Weight
505.64 g/mol
SMILES
CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N
InChIKey
YMARZQAQMVYCKC-OEMFJLHTSA-N
Last Updated: 2025-10-01 13:51
