Compound Q&A

How is Dimethyl (4-methoxybenzylidene)malonate (CAS: 7443-25-6) typically synthesized?

Answer

Dimethyl (4-methoxybenzylidene)malonate
Dimethyl (4-methoxybenzylidene)malonate is typically synthesized through an esterification reaction of malonoyl chloride with 4-methoxybenzyl alcohol. This process is catalyzed by an acid, such as sulfuric acid, and proceeds with a high yield of around 85-90%. The reaction is carried out at room temperature and is known for its good selectivity.

About

CAS No 7443-25-6
English Name Dimethyl (4-methoxybenzylidene)malonate
Molecular Formula C13H14O5
Molecular Weight 250.25 g/mol
SMILES COC1=CC=C(C=C1)C=C(C(=O)OC)C(=O)OC
InChIKey JMFYZMAVUHNCPW-UHFFFAOYSA-N
Last Updated: 2025-09-26 00:09

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