Compound Q&A
How is (4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline (CAS: 13504-85-3) typically synthesized?
Answer
![(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline](https://static.chemtradehub.com/structs/135/13504-85-3-96cf.webp "(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline")
(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline is synthesized by the condensation of benzyloxycarbonyl chloride with (4R)-4-hydroxy-L-proline. This reaction is catalyzed by triethylamine in dichloromethane. The product is purified by column chromatography, yielding a high yield of 80-85%.
About
CAS No
13504-85-3
English Name
(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline
Molecular Formula
C13H15NO5
Molecular Weight
265.265 g/mol
SMILES
O[C@@H]1C[C@H](N(C1)C(=O)OCc2ccccc2)C(=O)O
InChIKey
WWVCWLBEARZMAH-MNOVXSKESA-N
Last Updated: 2025-09-26 00:09
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