Compound Q&A
How is 2-(4-Chlorobenzyl)-1H-benzimidazole (CAS: 5468-66-6) typically synthesized?
Answer
2-(4-Chlorobenzyl)-1H-benzimidazole is typically synthesized by the condensation of 4-chlorobenzylamine with benzimidazole in the presence of a base such as sodium hydroxide. The reaction is performed in an aprotic solvent like dimethylformamide (DMF) at elevated temperatures. The yield is generally good, and the product is purified by recrystallization from ethanol.
About
CAS No
5468-66-6
English Name
2-(4-Chlorobenzyl)-1H-benzimidazole
Molecular Formula
C14H11ClN2
Molecular Weight
242.71 g/mol
SMILES
C1=CC=C2C(=C1)NC(=N2)CC3=CC=C(C=C3)Cl
InChIKey
COGUOPIIFAMLES-UHFFFAOYSA-N
Last Updated: 2025-09-23 10:23
