How is 2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0) typically synthesized?

2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0) is often synthesized via a condensation reaction of 2,4-dichloropyrimidine with methyl bromide, catalyzed by a transition metal such as copper. The reaction typically occurs under anhydrous conditions and requires the use of a mild base to enhance reactivity. The yield is generally high, with selectivity towards the desired product, and the method is well-documented in the literature.