2,4-Dichloro-5-methylpyrimidine(CAS: 1780-31-0)

2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0) is a crystalline solid with a molecular weight of approximately 203.03 g/mol. It has low water solubility and is moderately soluble in common organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions. The compound is known for its aromatic characteristics and can form hydrogen bonds with other molecules.

2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0) is often synthesized via a condensation reaction of 2,4-dichloropyrimidine with methyl bromide, catalyzed by a transition metal such as copper. The reaction typically occurs under anhydrous conditions and requires the use of a mild base to enhance reactivity. The yield is generally high, with selectivity towards the desired product, and the method is well-documented in the literature.

2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0) finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of certain drugs, in the polymer industry for developing specific polymers with unique properties, and in the sensor technology for creating chemical sensors. Additionally, it has been explored in semiconductor applications for its electronic properties.

When handling 2,4-Dichloro-5-methylpyrimidine (CAS: 1780-31-0), it is essential to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat to prevent skin and eye contact. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbents, and all waste should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.