How is Methyl 5-hydroxy-2-pyridinecarboxylate (CAS: 30766-12-2) typically synthesized?

Methyl 5-hydroxy-2-pyridinecarboxylate (CAS: 30766-12-2) is typically synthesized via an esterification reaction of 5-hydroxy-2-pyridinecarboxylic acid with methanol. Commonly, this is achieved using a strong acid catalyst like sulfuric acid or tosyl chloride. The reaction is conducted under mild conditions to ensure high selectivity and yield. The product can be purified by recrystallization from an appropriate solvent.