What regulatory guidelines apply to 1,3-Butadiene (CAS: 9003-17-2)?

1,3-Butadiene (CAS: 9003-17-2) is classified as a hazardous substance under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) due to its flammability and potential for skin and respiratory irritation. In Europe, it is regulated under REACH, which requires registration, evaluation, authorization, and restriction of chemicals. In the United States, it is listed under the EPA's Toxic Substances Control Act (TSCA) and is regulated by OSHA for workplace safety. FDA regulations may also apply if used in food contact applications.