Compound Q&A
How is (2R)-3-(4-bromophenyl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid (CAS: 79561-82-3) typically synthesized?
Answer
![(2R)-3-(4-bromophenyl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid](https://static.chemtradehub.com/structs/795/79561-82-3-2868.webp "(2R)-3-(4-bromophenyl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid")
(2R)-3-(4-bromophenyl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid is usually synthesized via the condensation of 4-bromophenylacetic acid with tert-butoxycarbonyl chloride in the presence of a base such as diisopropylethylamine. The reaction is typically conducted in an organic solvent like dichloromethane or tetrahydrofuran, with high selectivity and yields up to 90%. The product is then purified using column chromatography or recrystallization.
About
CAS No
79561-82-3
English Name
(2R)-3-(4-bromophenyl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
Molecular Formula
C14H18BrNO4
Molecular Weight
344.20500000000004 g/mol
SMILES
CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)Br)C(=O)O
InChIKey
ULNOXUAEIPUJMK-LLVKDONJSA-N
Last Updated: 2025-09-19 21:14
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