Compound Q&A
How is 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (CAS: 737789-87-6) typically synthesized?
Answer
![1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea](https://static.chemtradehub.com/structs/737/737789-87-6-923a.webp "1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea")
The compound is synthesized via a multi-step process involving the condensation of a pyridazinone derivative and a benzylamine followed by urea condensation. The synthesis typically uses a catalyst such as triphenylphosphine to enhance the selectivity and yield. The overall yield is approximately 75%.
About
CAS No
737789-87-6
English Name
1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea
Molecular Formula
C29H27F2N7O5S
Molecular Weight
623.64 g/mol
SMILES
CONC(=O)Nc1ccc(cc1)c2sc3n(Cc4c(F)cccc4F)c(=O)n(c5ccc(OC)nn5)c(=O)c3c2CN(C)C
InChIKey
AOMXMOCNKJTRQP-UHFFFAOYSA-N
Last Updated: 2025-09-16 13:49
![1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea — ShangHaiYiJiShengWuKeJiYouXianGongSiXiaoShouBu](https://static.chemtradehub.com/suppliers/67cecfe92b2de6e8e95a656d/67cecfe92b2de6e8e95a656d-logo.webp){kind=logo}