How is 1,2,3,4-Tetrafluoro-5-nitrobenzene (CAS: 5580-79-0) typically synthesized?

1,2,3,4-Tetrafluoro-5-nitrobenzene can be synthesized via nitration of 1,2,3,4-tetrafluorobenzene using concentrated nitric acid and sulfuric acid as the acid catalyst. The reaction is typically carried out at low temperature to control the reaction selectivity. The yield of the product is usually around 70-80%, and the method requires proper handling of the nitric acid to prevent unintended side reactions.