Compound Q&A
How is 2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1) typically synthesized?
Answer
2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1) can be synthesized by electrophilic chlorination of 6-fluorobenzenecarbaldehyde. Commonly, this involves treating 6-fluorobenzenecarbaldehyde with thionyl chloride in the presence of a suitable catalyst, such as aluminum chloride, to achieve high selectivity and yield. The reaction is typically performed under reflux conditions in anhydrous conditions to minimize side reactions.
About
CAS No
387-45-1
English Name
2-Chloro-6-fluorobenzaldehyde
Molecular Formula
C7H4ClFO
Molecular Weight
158.56 g/mol
SMILES
C1=CC(=C(C(=C1)Cl)C=O)F
InChIKey
OACPOWYLLGHGCR-UHFFFAOYSA-N
Last Updated: 2025-09-10 15:15
