2-Chloro-6-fluorobenzaldehyde(CAS: 387-45-1)

2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1) is a crystalline solid with a molecular weight of approximately 199.01 g/mol. It has a low solubility in water (less than 1 g/L at 20°C) but is more soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, typically undergoing nucleophilic substitution reactions. It is insoluble in nonpolar solvents such as hexane or toluene.

2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1) can be synthesized by electrophilic chlorination of 6-fluorobenzenecarbaldehyde. Commonly, this involves treating 6-fluorobenzenecarbaldehyde with thionyl chloride in the presence of a suitable catalyst, such as aluminum chloride, to achieve high selectivity and yield. The reaction is typically performed under reflux conditions in anhydrous conditions to minimize side reactions.

2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1) is primarily used in the pharmaceutical industry for the synthesis of various organic compounds and intermediates. It also finds applications in the production of resin and polymer compounds, and in the development of sensors and semiconductors due to its unique chemical reactivity and functional groups.

When handling 2-Chloro-6-fluorobenzaldehyde (CAS: 387-45-1), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or within a fume hood to minimize exposure to vapors. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated before resuming work. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.