Compound Q&A
How is 2-Methyl-2-propanyl {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate (CAS: 289042-12-2) typically synthesized?
Answer
![2-Methyl-2-propanyl {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate](https://static.chemtradehub.com/structs/289/289042-12-2-a9bd.webp "2-Methyl-2-propanyl {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate")
Synthesis typically involves multi-step processes, including the formation of an acetal followed by a ring-opening reaction with a pyrimidine derivative. Specific catalysts such as Lewis acids can be used to improve selectivity. The overall yield is moderate, around 50-70%, and the reaction is carried out under anhydrous conditions to prevent unwanted side reactions.
About
CAS No
289042-12-2
English Name
2-Methyl-2-propanyl {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate
Molecular Formula
C29H40FN3O6S
Molecular Weight
577.72 g/mol
EINECS
1806241-263-5
SMILES
CC(C)C1=NC(=NC(=C1C=CC2CC(OC(O2)(C)C)CC(=O)OC(C)(C)C)C3=CC=C(C=C3)F)N(C)S(=O)(=O)C
InChIKey
WIFPCEOJTKZGSA-UQECUQMJSA-N
Last Updated: 2025-09-10 15:15
![2-Methyl-2-propanyl {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate — Hubei Yangxin Pharmaceutical Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cded3957537e5c8069af88/67cded3957537e5c8069af88-logo.webp){kind=logo}